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<< Click to Display Table of Contents >> Apak-212 |
  
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<< Click to Display Table of Contents >> Apak-212 |
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: When DNA damage occurs, the ATM (ataxia-telangiectasia mutated) kinase phosphorylates APAK at specific sites (e.g., Ser68), causing it to dissociate from p53. This release allows p53 to activate genes like p53AIP1 , which initiate apoptosis. Characteristics of APAK-212
The construct is a research-grade tool designed to mimic or interfere with these interactions. Based on its classification in preclinical literature, it typically features: APAK-212
: Under normal (unstressed) conditions, APAK binds to p53 and recruits a corepressor complex (KAP-1 and HDAC1) to inhibit p53’s pro-apoptotic activity. : When DNA damage occurs, the ATM (ataxia-telangiectasia